Resident Evil is filled with collectibles and puzzles, and the latest Requiem is no different.
We already covered all Blood Specimens, but that is not the only environment puzzle in the game.
There are a total of 5 safes scattered across the campaign that hold a variation of loot; from Antique Coins to useful ammunition.
We’ve got you covered with all safe solutions, including the ones for the Insanity difficulty!
Bar & lounge safe code
The Bar & Lounge room is the first area that holds a safe in its location, albeit in a quite dangerous position as the room also has 2 Zombies and a Singer roaming about.
When entering the section the safe is located on the left side on the room, behind the bar. Make your way over there and interact with the safe.
The solution is: <10 >80 <30 (Left 10, Right 80, Left 30)
On Insanity difficulty it is: >20 <50 >30 (Right 20, Left 50, Right 30)
Doing so unlocks the safe and rewards you with 3 Antique Coins, grab them and turn around to also grab Grace’s S&S M232 Pistol on the bar itself. It is the better pistol for Grace’s sections, so don’t let it lie about!
examination room safe code
The next safe to be found is located in the Examination Room, though beware the way there is quite dangerous as Zombies, and potentially Chunk, are in your way.
Make your way over there and use the following solution: >30 <10 >50 (Right 30, Left 10, Right 50)
On Insanity the code is: <50 >30 <90 (Left 50, Right 30, Left 90)
Doing so rewards you with another 3 Antique Coins, which should be enough for you to purchase an upgrade or two at the Parlor.
Basement furnace safe code

The next safe takes place further into the story, all the way in the Basement area where you have to solve the Forklift and Joint Plug puzzles.
This safe can be found north of the Processing room in a room without a name.
You can enter it by either using a Joint Plug at the door or using the crawlspace in the Workshop.
Once there use this solution: >60 <40 >80 (Right 60, Left 40, Right 80)
On Insanity it is: <70 >50 <20 (Left 70, Right 50, Left 20)
Doing so rewards you with the Raccoon Roundup Map (Rhodes Hill), which will mark all Raccoon Toys on the Rhodes Hill section. However, you cannot revisit that area until your next playthrough.
ark sterilization chamber safe code

To reach this area you first need to navigate through the Licker filled Sterilization Chamber during the ARK section of the game.
At the end of the room you can find a locked safe, which you can open up with this solution: >10 <90 >20 (Right 10, Left 90, Right 20)
On Insanity: <80 >50 <0 (Left 80, Right 50, Left 0)
You will be rewarded with a Med Injector, Handgun Ammo x15, and a Molotov Cocktail.
Important supplies for getting through this section of the game, as you have quite the amount of enemies ahead of you.
ARK Monitor Control Room safe code

The Monitor Control Room is adjacent to the Lobby where you need two Orbs to open the door.
There are no enemies in the room, and the code is inside one of the containers in Bioweapon Repository 05.
The solution is: <50 >60 <80 (Left 50, Right 60, Left 80)
On Insanity: >20 <0 >70 (Right 20, Left 0, Right 70)
You will be rewarded with survival supplies such as a Med Injector, a Bottle of Acid and an Empty Bottle that can be crafted into either a Molotov or another Bottle of Acid, the latter being very effective against Lickers.
all safe codes listed

For players who just want a quick-reference list, here are all safe codes in Resident Evil Requiem, including their alternate combinations on Insanity difficulty.
Insanity Difficulty Safe Codes:
- Bar & Lounge safe code: >20 <50 >30
- Examination Room safe code: <50 >30 <90
- Basement safe code: <70 >50 <20
- Sterilization Chamber safe code: <80 >50 <0
- Monitor Control Room safe code: >20 <0 >70
Regular Difficulties Safe Codes:
- Bar & Lounge safe code: <10 >80 <30
- Examination Room safe code: >30 <10 >50
- Furnace Forklift room safe code: >60 <40 >80
- Sterilization Chamber safe code: >10 <90 >20
- Monitor Control Room safe code: <50 >60 <80